Finding your niche: cellular heterogeneity in asthma

DAY 3

Chaired by: Professor Liam Heaney (Belfast) and Dr Maisha Jabeen (Oxford)

9:00am	Overcrowding in the asthmatic airway: the consequences of bronchospasm Professor Jody Rosenblatt (London)
9:30am	Greater than the sum of their parts: mast cell – eosinophil interactions in asthma Professor Sven-Erik Dahlén (Sweden)
10:00am	Upside down: epithelial responses to eosinophil targeting Dr Hitasha Rupani (Southampton)

9:00 AM

90 MINUTE SESSION

Learning objectives

To understand the mechanobiological effects of bronchoconstriction on the airway epithelium, and how these processes may contribute to airways remodelling in asthma.
To explore the role of mast cells in asthma immunopathology and how bidirectional interactions with eosinophils impact the effector function of both cells.
To understand how targeting the downstream IL-5/eosinophil pathway may lead to improvements in upstream epithelial function in asthma.